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西那卡塞口服后2~6h血药浓度达峰值(Cmax)。西那卡塞与高脂肪食物同服,其Cmax和药时曲线下面积(AUC)分别增加82%和68%;与低脂肪食物同服,其Cmax和AUC分别增加65%和50%。西那卡塞吸收后血药浓度呈双相消除,消除t1/2为30~40h。连续给药7d血药浓度达稳态,Cmax和AUC随给药剂量的增大而增加。表观分布容积为1000L,表明西那卡塞分布广泛。西那卡塞进入人体后93%~97%与血浆蛋白结合。西那卡塞经多种酶代谢,主要有CYP3A4、CYP2D6、CYP1A2。主要经肾脏排出,占给药剂量的80%,约15%经粪便排出。中度及重度肝功
Cinacalcet 2 ~ 6h after oral administration of plasma concentration peak (Cmax). Cinacalcet combined with high fat diet had Cmax and AUC of 82% and 68%, respectively. Cmax and AUC increased 65% and 50% respectively with low fat diet. Cinacalcet after absorption of blood concentration was biphasic elimination, eliminating t1 / 2 for 30 ~ 40h. Serum concentrations of 7d continuous administration reached steady state, Cmax and AUC increased with the increase of the dose. The apparent volume of distribution is 1000L, indicating widespread cinacalcet. Cinacalcet 93% to 97% after entering the human body with plasma protein binding. Cinacalcet metabolism by a variety of enzymes, mainly CYP3A4, CYP2D6, CYP1A2. Mainly by the kidneys, accounting for 80% of the dose, about 15% of the excreted. Moderate and severe liver function