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目的探讨派丽奥与盐酸克林霉素治疗慢性牙周炎的临床疗效及其龈沟液中sICAM-1水平的影响。方法选取66例来医院就诊的慢些牙周炎患者,随机分为对照组和观察组,每组33例。对照组给予派丽奥治疗,观察组给予盐酸克林霉素治疗,观察两组患者的临床疗效及龈沟液中sICAM-1水平的变化。结果观察组的总有效率为93.94%明显高于对照组的75.76%(P<0.05);两组患者的sICAM-1浓度均比治疗前显著下降(P<0.05),观察组比对照组降低明显(P<0.05)。两组患者均未出现严重的不良反应。结论盐酸克林霉素治疗慢性牙周炎疗效优于派丽奥,能更有效地改善牙周炎的主要临床症状,效果显著,药效持久,且无严重的不良反应。
Objective To investigate the clinical efficacy of palio and clindamycin hydrochloride in the treatment of chronic periodontitis and the effect of sICAM-1 in gingival crevicular fluid. Methods Sixty-six patients with periodontitis were selected and randomly divided into control group and observation group, with 33 cases in each group. The control group was treated with Palio, and the observation group was treated with clindamycin hydrochloride. The clinical efficacy and sICAM-1 level in gingival crevicular fluid of the two groups were observed. Results The total effective rate in the observation group was 93.94%, which was significantly higher than that in the control group (75.76%, P <0.05). The concentrations of sICAM-1 in both groups were significantly lower than those before treatment (P <0.05) Obviously (P <0.05). No serious adverse reactions occurred in both groups. Conclusion Clindamycin Hydrochloride is superior to Paeli in the treatment of chronic periodontitis, which can effectively improve the main clinical symptoms of periodontitis. The effect is significant, lasting effect and no serious adverse reactions.