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小鼠内关穴注射胰岛素(2u/10g)后5分钟和15分钟血糖下降的百分率分别为40.13±11%和72.27±7.34%,与尾静脉注射组比较没有明显差异,而明显大于腹股沟皮下注射组。结果提示内关穴注射胰岛素的降糖作用与尾静脉注射一样,迅速而强大,有可能作为一种方便的途径代替静脉注射用于糖尿病酸中毒昏迷的治疗。内关穴注射~(125)Ⅰ-胰岛素后5分钟,血清和肝脏内放射活性明显小于尾静脉注射组;血清内放射活性虽大于皮下注射组,但肝脏内放射活性与皮下注射组无明显差异。提示内关穴注射胰岛素所产生的迅速而强大的降糖作用,并不完全是由于吸收快、血胰岛素浓度高的缘故,经络系统的循径感传现象有可能参与血糖的下降整调。
The percentages of blood glucose decrease at 5 minutes and 15 minutes after injection of insulin (2u/10g) at Neiguan Point in mice were 40.13±11% and 72.27±7.34%, respectively, which were not significantly different from those in the tail vein injection group but significantly larger than those in the inguinal subcutaneous injection. group. The results suggest that the hypoglycemic effect of injection of insulin at Neiguan points is as rapid and powerful as the tail vein injection, which may serve as a convenient alternative to intravenous injection for the treatment of diabetic acidosis coma. Five minutes after injection of ~(125)I-insulin at Neiguan point, the radioactivity in serum and liver was significantly lower than that in the tail vein injection group; serum radioactivity was greater than that in the subcutaneous injection group, but intrahepatic radioactivity was not significantly different from subcutaneous injection group. . The prompt and powerful hypoglycemic effect of insulin injection at Neiguan point is not entirely due to rapid absorption and high blood insulin concentration. The phenomenon of transmission through the meridian system may be involved in the down regulation of blood glucose.