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苦参的生物碱具有广泛的生物活性,它的有效成分之一——氧化苦参碱有显著地提高白血球的作用。我们以槐果碱为起始原料,经催化氛化得n-[13-~3H]-苦参碱,再经氧化得n-[13-~3H]-氧化苦参碱。本文介绍了槐果碱与苦参碱的薄层鉴别分离方法,证明槐果碱加氚确已完成,并证明了苦参碱的14-位氚是不稳定氚,而苦参碱的结构中确实有烯醇互变异构的存在。氧化苦参碱的模拟产品与氧化苦参碱的标准品的红外谱是完全一致的。
Alkaloids from Sophora flavescens have a wide range of biological activities. Oxymatrine, one of its active ingredients, has a significant effect on improving white blood cells. We used sophocarpine as starting material, and obtained n-[13-~3H]-matrine by catalytic nitration, and then obtained n-[13-~3H]-oxymatrine by oxidation. This paper introduced the method for the identification and separation of sophocarpine and matrine, which demonstrated that the sophocarpine addition was indeed completed, and proved that the 14-position of matrine is unstable and the structure of matrine There is indeed the presence of enol tautomerism. The infrared spectrum of the oxymatrine analog product and the oxymatrine standard product is exactly the same.