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Ames试验和枯草杆菌重组修复试验,都是近年来发展起来的筛选致癌物的短期试验方法。但研究指出,这两种方法对致癌性金属的敏感性有很大差异。为了解释这一现象,有人提出离子干扰假说,认为Ames试验所用的培养基中含有较多离子,如Mg,SO_4,PO_4等,这些离子可能干扰细菌对重金属的吸收。但目前尚未见有关这
Ames test and Bacillus subtilis recombinant repair test, are short-term test methods for screening carcinogens developed in recent years. However, research indicates that the sensitivity of these two methods to carcinogenic metals varies widely. To explain this phenomenon, the hypothesis of ion interference was proposed. The medium used in Ames test contains more ions such as Mg, SO 4, PO 4, etc. These ions may interfere with the bacteria’s absorption of heavy metals. But no one has seen it yet