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Aim: To assess the associations between nutrition supplements in infancy and later asthma and allergy in school- age children, and to explore the impact of environmental factors in early life. Methods: Five hundred and two children unde rwent clinical examination, skin prick test and a second parentally completed qu estionnaire within 2 y of a cross- sectional questionnairebased study, includin g 4585 primary school children (6- 16 y old) in 1994 from urban Oslo (37% ), t he mountainous area of Hallingdal (42% ), and the industrial, coastal area of O dda (21% ). The children were selected from the 1994 survey on the basis of rep orted diagnosed asthma (n=166), wheeze in the last 12 mo (n=155) and no asthma/n o wheeze (n=181). Questions were related to nutrition and environmental exposure in early life. Possible associations between allergic sensitization or asthma a t school age and exposures were estimated by logistic regression analysis, adjus ting for potential confounders. Results: Daily intake of fresh fruit or vegetabl es, but not extra vitamins or cod liver oil supplements, in infancy decreased th e risk of asthma (adjusted odds ratio (aOR) 0.57 (95% confidence interval (CI) : 0.37- 0.88). Early supplements of cod liver oil and extra vitamins were assoc iated with increased allergic sensitization (aOR 1.78 (95% CI: 1.03- 3.07) an d 1.71 (95% CI: 1.01- 2.88), respectively). A significantly higher prevalence of allergic sensitization was found in children living in Hallingdal compared t o Odda, while the latter children, on the other hand, had the highest prevalence of house dust mite allergy (p=0.001 vs Hallingdal and p=0.04 vs Oslo). Conclusi on: The present study suggests that the early introduction of daily fresh fruit or vegetables may decrease the risk of asthma after 1 y of life, whereas allergi c sensitization at school age seemed to increase with extra vitamin and cod live r oil supplements during infancy. Living area influenced allergic sensitization, with differences between coastal and inland areas.
Aim: To assess the associations between nutrition supplements in infancy and later asthma and allergy in school-age children, and to explore the impact of environmental factors in early life. Methods: Five hundred and two children unde rwent clinical examination, skin prick test and a second parentally completed qu estionnaire within 2 y of a sectional sectional questionnaire based study, includin g 4585 primary school children (6- 16 y old) in 1994 from urban Oslo (37%), t mountainous area of Hallingdal (42%) , and the industrial, coastal area of Oda (21%). The children were selected from the 1994 survey on the basis of rep orted diagnosed asthma (n = 166), wheeze in the last 12 mo (n = 155) and no Asthma / no wheeze (n = 181). Questions were related to nutrition and environmental exposure in early life. Possible associations between allergic sensitization or asthma at school age and exposures were estimated by logistic regression analysis, adjus ting for potential confounders. Results: Daily intake of fresh fruit or vegetabl es, but not extra vitamins or cod liver oil supplements, in infancy decreased th e risk of asthma (adjusted odds ratio (aOR) 0.57 (95% confidence interval (CI): 0.37-0.88) supplements of cod liver oil and extra vitamins were associated iated with increased allergic sensitization (aOR 1.78 (95% CI: 1.03-3.07) an d 1.71 (95% CI: 1.01-2.88), respectively). A significant over prevalence of allergic sensitization was found in children living in Hallingdal compared to Odda, while the latter latter, on the other hand, had the highest prevalence of house dust mite allergy (p = 0.001 vs Hallingdal and p = 0.04 vs Oslo). Conclusi on: The present study suggests that the early introduction of daily fresh fruit or vegetables may decrease the risk of asthma after 1 y of life, whereas allergi c sensitization at school age decreased to with with vitamin and cod live r oil supplements during infancy. Living area allergic sensitization ,with differences between coastal and inland areas.