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目的观察脆性组氨酸三联体(FHIT)在子宫内膜异位症中的表达。方法应用免疫组化SP法检测30例子宫内膜异位症异位内膜和在位内膜及30例同期单纯子宫肌瘤患者子宫内膜为对照组中FHIT蛋白的表达情况。结果 FHIT在正常子宫内膜、在位子宫内膜、异位子宫内膜中的阳性表达率逐渐降低(χ2=28.865,P<0.000 1),在内异症r-AFS分期中比较,在位子宫内膜FHIT的表达差异无统计学意义(χ2=2.337,P=0.341);而异位内膜中的FHIT表达差异有统计学意义,Ⅰ～Ⅱ期高于Ⅲ～Ⅳ期(χ2=6.816,P=0.019)。结论 FHIT与内异症的发生、发展关系密切。
Objective To investigate the expression of fragile histidine triad (FHIT) in endometriosis. Methods Immunohistochemical SP method was used to detect the expression of FHIT protein in 30 cases of endometriosis and 30 cases of endometrial uterine fibroids. Results The positive expression rate of FHIT in normal endometrium, endometriosis and ectopic endometrium decreased gradually (χ2 = 28.865, P <0.0001). Compared with that in endometriosis r-AFS staging There was no significant difference in the expression of FHIT in endometrium (χ2 = 2.337, P = 0.341), while the expression of FHIT in eutopic endometrium was significantly higher than that in stage Ⅲ ~ Ⅳ (χ2 = 6.816 , P = 0.019). Conclusion FHIT is closely related to the occurrence and development of endometriosis.