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一般常用两种方法初估有机化合物对人的致癌可能性,首先看它的化学结构是否与已知的致癌物类伺,其次是对与致癌物有关结构物质进行动物致癌测试。通过这些方法已经找到了许多新的致癌物质,但很耗费时间与资金。如果按照常规方法来检测环境和工业生产中各种化学物质的致癌性,就是在不久的将来,也难以办到。为此,就需要研究与建立致癌性的短期测试方法。本文的目的就是评价文献中已提出的短期测试方法,讨论它们的效果和不足之处,以便选择一些方法,作为致癌性筛试的基础,检出尚在应用中的可疑致癌物质;和使人们能够有效地避免采用一些还未了解的潜在致癌物。本研究采用120种化学物,其中58种为已知对
Two methods are generally used to evaluate the possibility of organic compounds carcinogenic to humans. First of all, to see whether its chemical structure is related to known carcinogens, and secondly to conduct animal carcinogenesis tests on carcinogenic substances. Many new carcinogens have been found through these methods but are time-consuming and costly. The detection of carcinogenicity of various chemical substances in the environment and in industrial production in accordance with conventional methods is difficult to achieve in the near future. To do this, we need to study and establish a short-term test of carcinogenicity. The purpose of this paper is to evaluate the short-term testing methods that have been proposed in the literature and to discuss their effectiveness and shortcomings in order to select methods that can be used as a basis for oncogenic screening to detect suspect carcinogens that are still in use; Can effectively avoid the use of some potential carcinogens not yet understood. The study used 120 chemicals, of which 58 were known pairs