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目的:探讨精神分裂症患者合并糖尿病对认知功能的影响。方法:对78例合并糖尿病的精神分裂症患者与118例无糖尿病也无糖耐量异常的精神分裂症患者采用阳性与阴性症状量表及5个认知功能量表评定临床症状与认知功能。结果:与不伴糖尿病的精神分裂症患者相比,伴糖尿病的精神分裂症患者处理速度、注意/工作记忆、执行功能和视觉记忆功能受损严重(P<0.05)。数字符号测验、连线测验A和B成绩与糖尿病病程与起病年龄相关联(P<0.01)。结论:精神分裂症伴发糖尿病者较不伴糖尿病者存在更严重的认知功能损害,提示治疗精神分裂症患者合并糖尿病可能有助于其认知功能的改善。
Objective: To investigate the effect of diabetes mellitus in patients with schizophrenia on cognitive function. Methods: 78 patients with schizophrenia with diabetes mellitus and 118 schizophrenia patients without diabetes mellitus and without glucose tolerance were assessed with clinical symptoms and cognitive function using positive and negative symptom scales and five cognitive function scales. Results: Treatment rate, attention / working memory, executive function, and visual memory were significantly impaired in schizophrenic patients with diabetes compared with those without schizophrenia (P <0.05). The digital sign test, connection test A and B scores correlated with duration of diabetes and onset of disease (P <0.01). Conclusion: There is more serious cognitive impairment in schizophrenia patients with diabetes than those without diabetes, which suggests that the treatment of schizophrenia patients with diabetes mellitus may be helpful for the improvement of cognitive function.