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内毒素血症已被认为是梗阻性黄疸患者术后发病和死亡的主要原因。革兰氏阴性细菌的毒素溶解产物是胆汁郁积者发生肝肾疾病、血液动力和凝血障碍的主要病因。曾报告梗阻性黄疸患者术后内毒素血症的发生率为50～75％。其病理机制尚不清楚;门静脉从肠道吸收细菌内毒素增多和Kupffer细胞功能低下可能是其重要因素。以前的研究者推测,胃肠道的胆块构成了重要的免疫屏障,阻止门脉吸收细菌内毒素,但尚未证实。本实验研究旨在重新评价上述假说。
Endotoxemia has been considered the main cause of postoperative morbidity and mortality in patients with obstructive jaundice. The toxin-dissolving product of Gram-negative bacteria is the major cause of liver and kidney disease, hemodynamic and coagulopathy in cholestasis. The incidence of postoperative endotoxemia in patients with obstructive jaundice was reported to be 50-75%. Its pathological mechanism is not clear; portal vein from the intestinal absorption of bacterial endotoxin and Kupffer cell dysfunction may be an important factor. Previous researchers speculated that the gut of the gastrointestinal tract constitutes an important immune barrier, preventing portal vein bacterial endotoxin absorption, but has not been confirmed. This experimental study aims to re-evaluate the above hypothesis.