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目的探讨检测患者血液甲种胎儿蛋白信使核糖核酸(alpha-fetoprotein messenger ribonucleic acid,AFP mRNA)及甲种胎儿蛋白(AFP)对判断肝癌术后复发或转移的临床意义。方法应用巢式 RT-PCR检测-4例肝癌患者术后2周、4周及6周时周围静脉血液中 AFP mRNA 及 AFP 的变化,并随访1年。结果 34例手术切除的肝癌患者中,术后6周时周围静脉血液中 AFP mRNA 仍呈阳性13例,术后6周内血液 AFP 持续阳性21例。术后1年内肿瘤复发或发现转移性病灶13例,其中7例血液 AFP mRNA及 AFP 均为阳性。结论术后检测血液 AFP mRNA 及 AFP 可更有效地判断肝癌的复发或转移。
Objective To explore the clinical significance of detecting alpha-fetoprotein messenger ribonucleic acid (AFP mRNA) and alpha fetoprotein (AFP) in patients with hepatoma recurrence or metastasis. Methods Nested RT-PCR was used to detect the change of peripheral blood AFP mRNA and AFP in 4 cases of liver cancer patients at 2 weeks, 4 weeks and 6 weeks after operation, and followed up for 1 year. Results In 34 patients with hepatocellular carcinoma who underwent surgical resection, AFP mRNA was still positive in peripheral venous blood at 13 weeks after operation. There were 21 cases of positive AFP in the blood within 6 weeks after surgery. Within 1 year after operation, tumors relapsed or metastatic lesions were found in 13 cases, of which 7 cases were positive for AFP mRNA and AFP. Conclusion Postoperative detection of blood AFP mRNA and AFP can more effectively determine the recurrence or metastasis of liver cancer.