Synthesis, Crystal Structure and Biological Properties of One Zinc(Ⅱ) Complex Based on 4-Acyl Pyrazo

• 作 者: 何川川 李玥 赵晶 许贯诚 孙素荣
• 机 构: Key Laboratory of Material and Technology for Clean Energy,Ministry of Education,Key Laboratory of A
• 出 处: 结构化学
• 发表日期: 2015年07期
• 关键词: bromide chelating DNA nitrate Zinc orthorhombic coordinate alkaline evaporation

[Zn(L)(CH3OH)3](H2L = N-(1-phenyl-3-methyl-4-propenylidene-5-pyrazolone)-salicylidene hydrazide) has been synthesized by the reaction of zinc nitrate and ligand H2 L. The complex crystallizes in orthorhombic system, space group Pbca with a = 5.888(15), b = 14.564(14), c = 22.20(2) , V = 5137(8) 3, Z = 8 and F(000) = 2184. The ligand serves as a negative bivalent tridentate chelating agent to coordinate with the central zinc(II) atom. DNA-binding was studied by UV-Vis spectral analysis and ethidium bromide(EB) displacement experiments. The results showed that the DNA-binding constant of the complex is 5.1×104 M–1. Antitumor activity of [Zn(L)(CH3OH)3] and the ligand have been investigated by MTT assay, which indicated that the complex has better cytotoxicity to Eca-109 and He La than free ligand.

[Zn (L) (CH3OH) 3] (H2L = N- (1-phenyl-3-methyl-4-propenylidene-5-pyrazolone) -salicylidene hydrazide has been synthesized by the reaction of zinc nitrate and ligand H2L. The complex crystallizes in an orthorhombic system, space group Pbca with a = 5.888 (15), b = 14.564 (14), c = 22.20 (2) , V = 5137 (8) = 2184. The ligand serves as a negative bivalent tridentate chelating agent to coordinate with the central zinc (II) atom. DNA-binding was studied by UV-Vis spectral analysis and ethidium bromide (EB) displacement experiments. The results showed that the DNA -binding constant of the complex is 5.1 x 104 M-1. Antitumor activity of [Zn (L) (CH3OH) 3] and the ligand have been investigated by MTT assay, which indicated that the complex has better cytotoxicity to Eca-109 and He La than free ligand.