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目的:探讨血液透析(HD)与血液灌流(HP)联合治疗尿毒症的临床效果。方法:选择维持血液透析的患者36例,随机分为观察组36例(HD+HP),对照组36例(HD),治疗6个月后观察两组治疗效果及相关指标。结果:观察组治疗后睡眠及皮肤瘙痒明显改善,甲状旁腺激素、血β2微球蛋白、血磷、钙磷乘积明显降低,与治疗前比较有统计学差异(P<0.05)。而对照组治疗前后无统计学意义(P>0.05)。结论:血液透析联合血液灌流治疗尿毒症安全有效。
Objective: To investigate the clinical effect of combined hemodialysis (HD) and hemoperfusion (HP) on uremia. Methods: Thirty-six patients with hemodialysis were randomly divided into observation group (HD + HP) and control group (36 cases). After 6 months of treatment, the therapeutic effect and related indicators were observed. Results: The sleep and pruritus of the observation group were significantly improved after treatment. The product of parathyroid hormone, blood β2 microglobulin, blood phosphorus and calcium and phosphorus decreased significantly compared with before treatment (P <0.05). The control group before and after treatment was not statistically significant (P> 0.05). Conclusion: Hemodialysis combined with hemoperfusion is safe and effective in the treatment of uremia.