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采用日立-835型氨基酸自动分析仪对33例重度妊高征和29例正常妊娠妇女血清中16种游离氨基酸及氮进行了定量分析,初步探讨了上述物质的异常改变与妊高征及其脑病发生的关系。发现重度妊高征母体血清氮基酸有如下变化;①高氨基酸血症和氨质血症;②高芳香族氨基酸(苯丙氨酸和酪氨酸)血症和低支链氨基酸/芳香氨基酸比值;③高苏、谷、甘、胱和精氨酸血症。子痫组的谷氨酸含量明显高于先兆子痫组(P<0.05)。重度妊高征存在着明显的血清氨基酸及氮的改变,并与高血压和妊高征性脑病有关。这可能有助于研究妊高征及妊高征性脑病的病理生理学。对于妊高征患者应慎用含芳香族氨基酸及谷氨酸等的复合氨基酸制剂。
In this study, 16 kinds of free amino acids and nitrogen in serum of 33 patients with severe PIH and 29 normal pregnant women were quantitatively analyzed by Hitachi-835 automatic amino acid analyzer. The abnormal changes of these substances and PIH and encephalopathy What happened? It was found that serum maternal serum amino acids in severe PIH were changed as follows: ①High aminoacidosis and hyperaemia; ②High aromatic amino acids (phenylalanine and tyrosine) and low-branched-chain amino acids / aromatic amino acids Ratio; high Su, Valley, Gan, bladder and argininemia. The levels of glutamate in eclampsia group were significantly higher than those in preeclampsia group (P <0.05). Severe pregnancy-induced hypertension there is a clear change of serum amino acids and nitrogen, and with hypertension and pregnancy-induced encephalopathy related. This may be helpful in studying the pathophysiology of PIH and PIH. PIH patients should be used with caution aromatic amino acids and glutamic acid and other composite amino acid preparations.