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目的探讨脂质代谢在子痫前期发病中的作用。方法用酶法检测28例重度子痫前期产妇(子痫前期组)和30例健康孕足月产妇(对照组)的外周血甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-c)、高密度脂蛋白胆固醇(HDL-c)水平;用油红染色法检测10例子痫前期组和10例对照组胎盘组织中脂质水平。结果子痫前期组外周血中TG、TC、LDL-c水平明显高于对照组(P<0.05),HDL-c水平明显低于对照组(P<0.05)。子痫前期胎盘组织中的脂质水平明显高于对照组(P<0.05)。结论子痫前期产妇存在明显的高脂质代谢异常。异常脂质代谢在子痫前期发病中起着一定的诱导作用。
Objective To investigate the role of lipid metabolism in the pathogenesis of preeclampsia. Methods The levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL) and total cholesterol in peripheral blood of 28 severe preeclampsia (preeclampsia group) and 30 healthy full term pregnant women Cholesterol (HDL-c) and high-density lipoprotein cholesterol (HDL-c) were measured by enzyme-linked immunosorbent assay (ELISA). Lipid levels in placenta of 10 preeclampsia and 10 control groups were detected by oil red staining. Results The levels of TG, TC and LDL-c in the peripheral blood of preeclampsia group were significantly higher than those of the control group (P <0.05), and the level of HDL-c was significantly lower than that of the control group (P <0.05). The level of lipid in placenta of preeclampsia was significantly higher than that of the control group (P <0.05). Conclusions There are obvious abnormalities of hyperlipidemia in pre-eclampsia women. Abnormal lipid metabolism plays a certain role in the pathogenesis of preeclampsia.