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利用单侧输尿管梗阻制备小鼠肾间质病变模型，观察了肾间质中细胞间粘附分子－１（ＩＣＡＭ－１）及Ｍａｃ－１阳性细胞的变化，并利用抗小鼠ＩＣＡＭ－１单克隆抗体对此模型进行了治疗。结果发现在单侧输尿管梗阻后第一天，梗阻侧肾间质小血管附近及近端肾小管上即有ＩＣＡＭ－１及ＩＣＡＭ－１ｍＲＮＡ的表达，第３～５天达高峰，第７天时开始下降。与此同时，肾间质内Ｍａｃ－１阳性的巨噬细胞也于梗阻后第３天开始出现，第７天达高峰。经抗ＩＣＡＭ－１单克隆抗体治疗后，ＩＣＡＭ－１及Ｍａｃ－１的表达均延迟出现并明显减弱，肾间质病理改变亦有所减轻。
A rat model of renal interstitial lesions was established by unilateral ureteral obstruction. The changes of intercellular adhesion molecule-1 (ICAM-1) and Mac-1 positive cells in renal interstitium were observed. Anti-mouse ICAM-1 This model was treated with a monoclonal antibody. The results showed that on the first day after unilateral ureteral obstruction, the expression of ICAM-1 and ICAM-1 mRNA in the proximal renal tubules near the obstructed lateral renal tubules reached the peak on the 3rd to 5th days and began on the 7th day decline. Meanwhile, Mac-1-positive macrophages in the renal interstitium also began to appear on the third day after obstruction and peaked on the seventh day. After ICAM-1 monoclonal antibody treatment, the expression of ICAM-1 and Mac-1 were delayed and significantly decreased, and the pathological changes of renal interstitium were also alleviated.