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目的 观察用 0 .3%妥布霉素滴眼液治疗绿脓杆菌性角膜溃疡的临床疗效。方法 采用回顾性分析方法 ,选择我院近 6年来绿脓杆菌性角膜溃疡的病例 97例 ,分三个治疗组 ,分别用妥布霉素、氧氟沙星、庆大霉素治疗 ,根据临床检查分析其药物敏感情况及治疗效果。结果 97例细菌培养阳性的患者中 ,妥布霉素组药物敏感率为 88.6 % ,氧氟沙星组为 84 .3% ,两组统计学处理无显著差异 ,庆大霉素组敏感率为 6 6 .7% ,与妥布霉素组比较有显著差异 (P <0 .0 5 )。妥布霉素组治疗有效率 88.6 % ,氧氟沙星组为 81.3% ,两组统计学处理无显著差异 ,庆大霉素有效率为 6 0 .0 % ,与妥布霉素相比较有显著差异 (P <0 .0 5 )。结论 妥布霉素对绿脓杆菌有较高的敏感性 ,早期及时应用妥布霉素滴眼液治疗绿脓杆菌性角膜溃疡能得到较好疗效 ,故妥布霉素滴液可考虑为治疗绿脓杆菌性角膜溃疡的一线药物
Objective To observe the curative effect of 0.3% tobramycin eye drops in the treatment of Pseudomonas aeruginosa corneal ulcer. Methods A retrospective analysis was used to select 97 cases of Pseudomonas aeruginosa corneal ulcer in the past 6 years in our hospital. The patients were divided into three treatment groups, respectively treated with tobramycin, ofloxacin and gentamicin, Check the analysis of the drug sensitivity and treatment. Results Among the 97 bacterial culture positive patients, the drug sensitivity of tobramycin group was 88.6% and that of ofloxacin group was 84.3%. There was no significant difference between the two groups. The sensitivity of gentamycin group was 6 6 .7%, compared with tobramycin group was significantly different (P <0. 05). Tobramycin group, the effective rate was 88.6%, ofloxacin group was 81.3%, no significant difference between the two groups of statistical analysis, gentamicin efficiency was 60.0%, compared with tobramycin Significant difference (P <0. 05). Conclusion Tobramycin has a higher sensitivity to Pseudomonas aeruginosa, early and timely application of tobramycin eye drops treatment of Pseudomonas aeruginosa corneal ulcer can get better effect, so Tobramycin infusion can be considered for treatment Pseudomonas aeruginosa ulcer first-line drugs