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细菌的耐药性,尤其是多重耐药已成为临床治疗的大难题。修饰酶及灭活酶的产生、抗生素作用靶位的改变以及利用膜蛋白的缺失与主动外排泵系统过表达来减少抗生素在细胞内的浓度,是细菌的几个重要耐药机制。整合子介导耐药基因在染色体、质粒及转座子之间移动,从而导致细菌耐药性的传播,是细菌耐药性迅猛发展的重要原因。
Bacterial drug resistance, especially multi-drug resistance has become a big problem for clinical treatment. Modification of enzyme and enzyme inactivation, changes in the role of antibiotics target and the use of membrane protein deletion and active efflux pump system to reduce the concentration of antibiotics in the cell concentration, is a bacterial resistance to several important mechanisms. Integrons mediate the movement of drug-resistant genes between chromosomes, plasmids and transposons, leading to the spread of bacterial resistance, which is an important reason for the rapid development of bacterial resistance.