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细胞之间黏附较差是肿瘤细胞的一项重要的基本特征。有研究表明,细胞间黏附主要受多种膜蛋白调节,钙黏蛋白家族是其重要的成员,其中E-钙黏素(E-cadherin)是近年来研究的较多的一类肿瘤抑制因子[1]。E-cadherin是一类单拱桥的跨膜蛋白,大部分分布于胞浆区,主要表达于上皮细胞中。E-cadherin已作为抑癌基因用于评价乳腺癌的预后[1-2]。E-cadherin的表达与肿瘤的侵袭转移密切相关,实验表明其在恶性程度较高的乳腺癌细胞中表达往往都是下调甚至是缺失的,在肿瘤发生、发展的后期,其功能也会受到干扰和抑制。其在上皮组织间质化(EMT)这一过程也起到了至关重要的作用。E-cadherin的表达下调或缺失,在肿瘤由良
Poor adhesion between cells is an important basic feature of tumor cells. Studies have shown that intercellular adhesion mainly by a variety of membrane protein regulation, cadherin family is an important member of which E-cadherin (E-cadherin) is a more recent study of a class of tumor suppressor [ 1]. E-cadherin is a type of single arch bridge transmembrane protein, most of the distribution in the cytoplasmic region, mainly in the epithelial cells. E-cadherin has been used as a tumor suppressor gene in the evaluation of the prognosis of breast cancer [1-2]. The expression of E-cadherin is closely related to tumor invasion and metastasis. Experiments show that the expression of E-cadherin is often down-regulated or even absent in the malignant breast cancer cells. In the later stage of tumorigenesis and development, the function of E-cadherin may be disturbed And inhibition. It also plays a crucial role in the process of epithelial tissue interstitialisation (EMT). E-cadherin expression is down-regulated or absent in tumors by good