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目的 :为探讨血型抗原消减在膀胱癌定量辅助诊断方面的应用价值。方法 :应用免疫组织化学ABC法检测35例膀胱移行细胞癌ABO(H)组织血型抗原 ,观察血型物质的消减与其病理形态学的关系。结果 :血型物质显著消减 ,占82 .8% ,性别、年龄、肿瘤形态和类型之间消减率没有显著性差别 ,但完全消减的发生率存在显著差异 ,5 0岁以上患者 ,组织血型为A型、无蒂、浸润型、分化为II级和III级的肿瘤均显著升高。结论 :组织血型抗原完全消失与肿瘤分化程度及异型性密切相关 ,结合移行细胞癌形态学变化 ,用免疫酶标法检测组织中的血型抗原作为一种辅助诊断手段是判断膀胱癌的生物学行为和分化程度的重要客观指标。
Objective: To investigate the value of blood group antigen depletion in the quantitative diagnosis of bladder cancer. Methods: Immunohistochemical ABC method was used to detect the blood group antigens of ABO (H) in 35 cases of transitional cell carcinoma of the bladder. The relationship between the reduction of blood group substances and the pathological morphology was observed. Results: There was a significant decrease of blood type substance, accounting for 82.8%. There was no significant difference in the abatement rate of gender, age, tumor morphology and type, but there was a significant difference in the complete abatement rate. In patients over 50 years of age, the blood type was A Type, pedunculated, infiltrative, differentiated into grade II and III tumors were significantly higher. Conclusion: The complete disappearance of blood group antigen is closely related to the degree of tumor differentiation and atypia. Combined with the morphological changes of transitional cell carcinoma, the detection of blood group antigen in the tissue by immunoenzyme-linked immunosorbent assay is a useful diagnostic tool to judge the biological behavior of bladder cancer And the degree of differentiation of important objective indicators.