Synthesis,Crystal Structure and Antifungal Activity of N-((2,6-Difluorophenyl)carbamoyl)-1,3-dimethy

• 作 者: 孙娜波 翟志文 沈钟华 翁建全 谭成侠 刘幸海 韩亮
• 机 构: College of Biology and Environmental Engineering,Zhejiang Shuren University,College of Chemical Engi
• 出 处: 结构化学
• 发表日期: 2017年10期
• 关键词: pyrazole antifungal preliminary monoclinic carbonyl instrument anhydride bonds i

The title compound N-((2,6-difluorophenyl)carbamoyl)-1,3-dimethyl-1 H-pyrazole-4-carboxamide(C_(13)H_(12)F_2N_4O_2) was synthesized, and its structure was confirmed by ~1H NMR,HRMS and X-ray diffraction. It crystallizes in the monoclinic system, space group P2_(1/c) with a = 9.50(2), b = 10.11(2), c = 14.07(3) ?, β = 102.15(3)°, Dc = 1.480 g/cm~3, Z = 4, V = 1320(5) ?~3, the final R = 0.0789 and wR = 0.1860 for 1054 observed reflections with I > 2σ(I). The preliminary biological test shows that the title compound has weak antifungal activities.

The title compound N - ((2,6-difluorophenyl) carbamoyl) -1,3-dimethyl-1 H-pyrazole-4-carboxamide 1H NMR, HRMS and X-ray diffraction. It crystallizes in the monoclinic system with space group P2_ (1 / c) with a = 9.50 (2), b = 10.11 (2), c = 14.07 The final R = 0.0789 and wR = 0.1860 for 1054 with the reflections with I> 2σ (I) = 102.15 (3) °, Dc = 1.480 g / cm 3, Z = 4 and V = 1320 (5) The preliminary biological test shows that the title compound has weak antifungal activities.