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目的探讨细胞粘附分子ＣＤ６２Ｐ（Ｐ选择素）在胃癌的表达及与其生物学行为的关系，并进行临床病理学评价。方法采用免疫组化方法（ＳＰ法）观察了ＣＤ６２Ｐ在６８例胃癌原发灶中的表达情况，对胃癌标本进行系统病理学检查。结果非癌胃组织未见ＣＤ６２Ｐ表达，胃癌组织中ＣＤ６２Ｐ表达阳性率为５６％（３８／６８）。阳性表达在癌组织血管内皮细胞上，部分癌细胞也可见ＣＤ６２Ｐ表达。在浸透浆膜（Ｔ３、Ｔ４）、淋巴结转移数超过５个、转移率大于５０％、转移至Ⅱ站以远及Ⅲ、Ⅳ期胃癌ＣＤ６２Ｐ表达显著增强（Ｐ＜００５）。结论ＣＤ６２Ｐ与胃癌的生物学行为密切相关，其表达的检测对评估胃癌淋巴结转移程度和分析病期可能有一定价值。
Objective To investigate the expression of cell adhesion molecule CD62P (Pselectin) in gastric cancer and its relationship with biological behaviors, and to evaluate the clinical pathology. Methods Immunohistochemical method (SP method) was used to observe the expression of CD62P in 68 cases of primary gastric cancer. The pathological examination of gastric cancer specimens was performed. Results There was no expression of CD62P in non-cancerous gastric tissues. The positive rate of CD62P expression in gastric cancer tissues was 56% (38/68). Positive expression in cancer tissue vascular endothelial cells, some cancer cells can also be found in CD62P expression. In the osmotic membrane (T3, T4), the number of lymph node metastasis was more than 5, the metastasis rate was greater than 50%, the distant metastasis to II station, and the expression of CD62P in stage III and IV gastric cancer was significantly increased (P < 0.05). Conclusion CD62P is closely related to the biological behavior of gastric cancer. The detection of its expression may be of value in evaluating the degree of lymph node metastasis of gastric cancer and analyzing the disease stage.