Synthesis, Crystal Structure and Antitumor Activities of 2-Acyl-β-lactam-2-carboxamides

• 作 者: 高海涛 王红梅 侯娜 郭兴荣 曾小华 胡扬根
• 机 构: CollegeofPharmacy,LaboratoryofChineseHerbalPharmacology,HubeiKeyLaboratoryofWudangLocalChineseMedici
• 出 处: 结构化学
• 发表日期: 2019年3期
• 关键词: crystal structure 2-acyl-β-lactam-2-carboxamides SYNTHESIS CYTOTOXIC activity
• 基金项目: the National Natural Science Foundation of China (No 81773746),the Open Project of Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine (No WDCM009 and 2011JH-2

A series of 2-acyl-β-lactam-2-carboxamides was prepared through a tandem Ugi 4 CC/SN cyclization of bromoacetic acid, primary amine, arylglyoxal, and isocyanide. All of them were characterized by NMR, IR, MS and elemental analysis. Meanwhile, the single c