论文部分内容阅读
目的 回顾性分析2 32例葡萄膜黑色素瘤(UvealMelanoma ,UM )的临床组织病理学特征,为临床诊断和选择治疗方法提供依据。方法 对北京同仁医院眼病理室15年间(1990年～2 0 0 4年8月)存档的2 32例葡萄膜黑色素瘤的临床及病理资料进行回顾性分析。结果 葡萄膜黑色素瘤患者以中年人居多,平均年龄4 4. 10岁,发病无性别和眼别差异,男女之比1 0 7∶1,左、右眼发病比1∶1 15。6 9 .8%的患者就诊主诉视物模糊或视力下降,2 1. 1%出现眼前黑影遮挡、视野缺损等症状,其症状伴随肿瘤的不断发展而变化。发病时间平均192 . 3天,发病时间在一年之内者2 5例(92 . 7% )。组织病理学检查,大体所见多4 9. 1%呈局限扁平结节状生长,4 8. 3%为蘑菇状球形生长;病理学分型以棱形细胞型多见(5 0 .0 % )。侵犯巩膜导管以上皮样细胞型多见。结论 葡萄膜黑色素瘤应综合临床及辅助检查争取早期诊断、早期治疗
Objective To retrospectively analyze the clinical histopathological features of 2 32 cases of uveal melanoma (UM) and provide the basis for clinical diagnosis and treatment selection. Methods The clinical and pathological data of 232 cases of uveal melanoma, which were archived in Department of Ophthalmology, Beijing Tongren Hospital during 15 years (from 1990 to August 2004), were retrospectively analyzed. Results The majority of uveal melanoma patients were middle-aged with an average age of 4.10 years. There was no difference in sex and eyes between the two groups. The ratio of men to women was 107.0 and the ratio of left and right eyes was 1: 15.69 .8% of patients complained of obstructive or vision loss, 21.1% occured in immediate view, visual field defects and other symptoms, the symptoms associated with the continuous development of the tumor changes. The average onset time was 192.3 days, with onset time of 25 cases (92.7%) within one year. Histopathological examination showed that the lesions were mostly flattened nodularly with the growth rate of 41.9%, and the growth of mushroom-shaped cells was 43.3%. The most common pathological types were prismatic cells (50.0%) . Invasion of the scleral catheter epithelioid cell type more common. Conclusion Uveal melanoma should be integrated clinical and laboratory tests for early diagnosis and early treatment