Agmatine reduces nitric oxide synthase expression and peroxynitrite formation in the cerebral cortex

• 作 者: Chin Hee Mun Won Taek Lee Kyun
• 机 构: DepartmentofAnatomy,BrainKorea21ProjectforMedicalScience
• 出 处: 中国神经再生研究：英文版
• 发表日期: 2010年23期
• 关键词: 诱导型一氧化氮合酶 脑缺血再灌注 大脑皮质 胍丁胺 过氧 精氨酸脱羧酶 暂时性 皮层神经元 agmatine global cerebral ischemia
• 基金项目: Supported by： a grant of the Korea Healthcare Technology R＆D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea, No. A080959,Acknowledgments： The authors thank the authorities

Agmatine, an analog of L-arginine, is an endogenous substance synthesized by arginine decarboxylase, which has been shown to possess neuroprotective effects following brain ischemia. Nitric oxide is generated by sequential oxidation of the guanidinium gro