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作者对磺酰脲受体、离子通道及胰岛素分泌之间的关系进行了实验研究和阐述。 β细胞有多种离子通道调节其兴奋性。1981年,Hamill等人发明的斑—钳技术(Patchclamptechnique)可对单离子通道的电流进行研究。当磺酰脲类使β细胞的受体达到饱和的浓度时,可与细胞膜上的ATP抑制性K~+通道的外表面的蛋白质结合,抑制通道电的活性,使细胞内的K~+外流减少、静息膜电位降低,导致细胞去极化,造成电压
The author of sulfonylurea receptors, ion channels and insulin secretion between the relationship between the experimental study and elaboration. Beta cells have a variety of ion channels to regulate their excitability. In 1981, the patch-clamp technique invented by Hamill et al. Studied the current of a single ion channel. When sulphonylureas saturate β-cell receptors, they bind to proteins on the outer surface of the ATP-inhibitory K ~ + channels on the cell membrane, inhibit the activity of the channels, and lead to K ~ + efflux in the cells Reduce, resting membrane potential decreases, leading to cell depolarization, resulting in voltage