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目的探讨真菌诱发院内感染的检验方法及其诊断价值。方法 120例院内真菌感染患者,均在入院后48 h以上发生感染,感染为新发或者在原感染基础上加重。按照其用药治疗前是否接受真菌检验分为观察组和对照组,各60例。对照组患者在感染发生后未接受真菌检验即按照临床经验给予广谱抗生素进行治疗;观察组患者在感染发生后则先行真菌检验,再进行对症治疗。记录比较两组患者的真菌转阴时间、体温恢复时间、住院时间等指标及治疗效果。结果观察组患者的治疗有效率为93.33%,真菌转阴时间为(5.2±1.3)d,体温恢复时间为(3.3±0.9)d,住院时间为(7.7±1.6)d,均优于对照组的76.67%、(9.8±1.9)d、(5.4±1.2)d、(13.5±2.6)d,差异有统计学意义(P<0.05)。结论对真菌诱发的院内感染进行早期检查对于感染的治疗、药物的合理应用都有极高的指导意义,有利于患者病情的快速恢复,效果显著,值得临床推广应用。
Objective To investigate the test method and its diagnostic value of fungal-induced nosocomial infection. Methods 120 cases of nosocomial fungal infections were infected more than 48 h after admission, the new infection or increased on the basis of the original infection. In accordance with whether the treatment before receiving the fungal test was divided into observation group and control group, 60 cases each. Patients in the control group were treated with broad-spectrum antibiotics according to clinical experience without receiving fungal tests after the onset of infection. Patients in the observation group were given fungal tests after the infection and symptomatic treatment was performed. Records were compared between the two groups of patients fungal overcast time, body temperature recovery time, hospitalization and other indicators and treatment. Results The effective rate of treatment in observation group was 93.33%, time of fungus negative conversion was (5.2 ± 1.3) days, body temperature recovery time was (3.3 ± 0.9) days and hospitalization time was (7.7 ± 1.6) days, both of which were better than those in control group (9.8 ± 1.9) d, (5.4 ± 1.2) d and (13.5 ± 2.6) d, respectively. There was significant difference between the two groups (P <0.05). Conclusion Early detection of nosocomial infections caused by fungi has a very high guiding significance for the treatment of infections and the rational application of drugs, which is beneficial to the rapid recovery of patients’ condition and has remarkable effect. It is worthy of clinical application.