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近年来,随着对胃酸分泌机制的深入了解,已经认识到壁细胞的氢-钾腺苷三磷酸酶(H~+、K~+-ATP酶)是胃酸分泌的最后环节,且对该酶的性质和在胃酸分泌中的作用进行了广泛地研究,同时也发现一些药物对此酶具有抑制作用,这些研究对消化性溃疡的治疗有重要意义。本文就这些研究作一简要介绍。 H~+、K~+-ATP酶的特性及其转运机制一般特性目前已经在许多动物和人的胃壁细胞中发现有H~+、K~+-ATP酶存在。该酶属ATP酶类,其催化亚单位是分子量约为10万道尔顿左右的多肽,主要位于微粒体上。但其在壁细胞内的位置并非一层不
In recent years, with the deep understanding of the mechanism of gastric acid secretion, it has been recognized that parietal cells of hydrogen - potassium adenosine triphosphatase (H ~ +, K ~ + -ATPase) is the last step in gastric acid secretion, and the enzyme The nature and role in gastric acid secretion has been extensively studied, but also found that some drugs have an inhibitory effect on this enzyme, these studies on the treatment of peptic ulcer is of great significance. This article gives a brief introduction to these studies. Characteristics of H ~ +, K ~ + -ATPase and Its General Mechanism of Transport Mechanism At present, H ~ + and K ~ + -ATPase have been found in many animal and human gastric parietal cells. The enzyme is ATP enzyme, the catalytic subunit is a molecular weight of about 100,000 Daltons of the polypeptide, mainly located in the microsome. But its location in parietal cells is not a layer