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杀死瘤细胞的理想药物应是识别瘤细胞,并有效地杀死瘤细胞,而不损害正常的细胞。科学家发现了一种制作能识别瘤细胞上的标记的蛋白方法时,看来一种理想的药物可能很快产生。这种有高度特异性的蛋白称为单克隆抗体,第二步是将每个抗体与一种霉素蓖麻蛋白连接。问题是蓖麻蛋白的毒性太大,只能在疾病危及生命时作为最后的治疗方法。剑桥阿顿布鲁斯医院的Steve Cobbold等认为,他们可能找到一种方法,这种方法可制造出有致死力的单克隆抗体,而不需将毒性药物附着在抗体上。 Cobbold等证实,将牢牢固定在抗原上的
The ideal drug to kill the tumor cells should be to identify the tumor cells and effectively kill the tumor cells without damaging the normal cells. When scientists find a way to make proteins that recognize markers on tumor cells, it seems like an ideal drug may be produced sooner. This highly specific protein is called a monoclonal antibody, and the second step is to attach each antibody to a mycotinoid ricin. The problem is that ricin is too toxic and can only be used as a last resort when the disease is life-threatening. Steve Cobbold of Atumbruch Hospital in Cambridge believes that they may find a way to create lethal monoclonal antibodies without the need to attach toxic drugs to the antibodies. Cobbold and other confirmed that it will be firmly fixed on the antigen