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目的:通过中药配合半剂量激素吸入与全剂量激素吸入治疗儿童哮喘的临床对照,揭示中药治疗哮喘可能起到“节约”激素的作用,同时更有利于控制哮喘症状。方法:本研究为随机、对照研究,60例轻度持续哮喘患者被随机分配至治疗组和对照组,治疗4周。比较两种治疗方案的临床疗效和抗炎作用。结果:①在治疗第4周,治疗组达到良好控制比例为43.3%(13/30),对照组达到良好控制比例为36.7%(11/30),两组相比无显著差异。②与治疗前相比,治疗结束后,两组患者哮喘症状评分均显著减少(P<0.05),两组间相比无显著性差异。③两组患者治疗前后肺功能各项指标相比较均无显著性差异。结论:中药配合半剂量吸入性糖皮质激素与全剂量吸入性糖皮质激素(ICS)对治疗轻度持续哮喘在控制哮喘、改善症状和抗气道炎症有相同的疗效。速效平喘合剂颗粒和西药联合可产生协同的治疗作用。
OBJECTIVE: To establish a clinical control of children asthma by combining traditional Chinese medicine with half-dose hormone inhalation and full-dose hormone inhalation, revealing that traditional Chinese medicine treatment of asthma may play a role of “saving” hormones and more conducive to the control of asthma symptoms. METHODS: This randomized, controlled study of 60 patients with mild persistent asthma was randomized to treatment and control groups for 4 weeks. Compare the clinical efficacy and anti-inflammatory effects of the two treatment options. Results: ① In the fourth week of treatment, the rate of good control in the treatment group was 43.3% (13/30), and that of the control group was 36.7% (11/30). There was no significant difference between the two groups. ② Compared with those before treatment, the scores of asthma symptom in both groups were significantly decreased after treatment (P <0.05), there was no significant difference between the two groups. ③ There was no significant difference in the indexes of pulmonary function between the two groups before and after treatment. Conclusion: The combination of half dose inhaled glucocorticoid and full dose inhaled glucocorticoid (ICS) has the same effect on the treatment of mild persistent asthma in asthma control, amelioration of symptoms and anti-airway inflammation. Quick-acting asthma mixture granules and western medicine can produce a synergistic therapeutic effect.