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作者对14例恶性骨肿瘤和14例良性骨肿瘤患者与15例正常成入的外周血淋巴细胞染色体数目改变、结构畸变及做孩率进行了研究，结果：恶性组染色体的平均值，正常二倍体81．9％，非正常二倍体18．1％，结构畸变率5.9％，微核率7．3‰，与良性骨肿瘤组的94．4％、5．6％、2.14％、3．1‰。及正常人群的976％、2．4％，0．93％，又4‰。相比较，存在高度显著差异，P＜0．01。在本实验中，骨肿瘤染色体数目及结构畸变和微核率的增加，可能是患者全身染色体不稳定的表现，其本质与DNA的修复缺陷有关。同时在临床上对恶性及良性骨肿瘤的鉴别诊断具有重要意义。
The authors studied chromosome numbers, structural aberrations, and childbirth rates in 14 patients with malignant bone tumors, 14 patients with benign bone tumors, and 15 normal peripheral blood lymphocytes. Results: Averages of chromosomes in malignant groups, normal two Ploid 81.9%, abnormal diploid 18.1%, structural aberration rate 5.9%, micronuclear rate 7.3%, and 94.4%, 5.6%, 2.14%, and benign bone tumors. 3.1‰. And the normal population was 976%, 2.4%, 0.93%, and 4%. In comparison, there was a highly significant difference, P<0.01. In this experiment, the increase in chromosome number, structural aberrations, and micronucleus frequency of bone tumors may be the manifestation of systemic chromosomal instability in patients. Its nature is related to DNA repair defects. At the same time, it has important clinical significance in the differential diagnosis of malignant and benign bone tumors.