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骨质疏松的主要危害是并发骨折，而骨折除了由骨量减少引起外，骨结构的变化也有重要影响。本文通过扫描电镜，对不同处理时间的大鼠胫骨近瑞干骺端松质骨进行观察，卵巢切除和固定均可引起松质骨的三维结构变化，表现为骨小梁变细、表面不光滑，骨小梁连续性中断等，骨小梁间连接遭到破坏，因而引起松质骨的总体三维结构损害，其力学强度将明显下降，骨折危险性增加．此外，本研究还发现，卵巢切除和固定双重因素并存时，松质骨结构改变更显著，骨小梁的连续破坏更严重，提示多因素作用可能明显地进一步增加骨折危险性。
The main risk of osteoporosis is concurrent fractures, fractures in addition to caused by decreased bone mass, bone structure changes also have a significant impact. In this paper, by scanning electron microscopy, different treatment time rat proximal tibia metaphyseal cancellous bone observation, ovariectomy and fixation can cause three-dimensional structural changes of cancellous bone, the performance of trabecular bone thinning, the surface is not smooth , Traumatic continuity of trabeculae, trabecular connection was destroyed, causing the overall three-dimensional structure of cancellous bone damage, the mechanical strength will be significantly reduced, the risk of fracture increased. In addition, this study also found that the coexistence of ovarian removal and fixation of two factors, the cancellous bone structure changes more pronounced, trabecular continuous destruction is more serious, suggesting that multiple factors may significantly increase the risk of fracture.