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目的:研究左氧氟沙星三联方案补救根治幽门螺杆菌(Hp)的疗效和药物不良反应。方法:经传统三联根除Hp治疗失败患者116例,随机分为A、B两组,A组60例,给予以左氧氟沙星为基础的三联补救治疗10 d;B组56例给予常规四联补救治疗10 d,观察两组疗效及不良反应。结果:A组54例完成治疗及随访,其中50例补救治疗成功,7例发生药物不良反应;B组51例完成治疗及随访,其中39例补救治疗成功,7例发生药物不良反应。A组的Hp根除率明显高于B组(P<0.05)。结论:以左氧氟沙星为主的三联方案补救根治Hp的疗效优于常规四联补救治疗,疗程短、不良反应少,值得临床推广。
Objective: To study the efficacy and adverse drug reactions of levofloxacin triple regimen in the cure of Helicobacter pylori (Hp). Methods: One hundred and sixty-six patients were randomly divided into A and B groups. A group (60 cases) received levofloxacin-based triple-salvage therapy for 10 days, and group B (56 cases) received conventional quadruple salvage therapy d, observe the two groups efficacy and adverse reactions. Results: A group of 54 patients completed the treatment and follow-up, of which 50 cases of successful treatment, 7 cases of adverse drug reactions; B group of 51 patients completed the treatment and follow-up, of which 39 cases of remedial treatment success, 7 cases of adverse drug reactions. Hp eradication rate in group A was significantly higher than that in group B (P <0.05). Conclusion: The levofloxacin-based triple regimen is superior to conventional quadruple salvage in the treatment of Hp. The short course of treatment and few adverse reactions are worthy of clinical promotion.