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目的通过探讨人乳头状瘤病毒(HPV)感染检测在未明确诊断的宫颈非典型鳞状上皮细胞(ASCUS)妇女分流管理中的价值,以确定合理分流方法。方法收集2009年1月-2012年12月体检采用薄层液基细胞学(TCT)方法,进行宫颈癌(ICC)筛查的5480名妇女资料,对TCT检测确诊为ASCUS的152名妇女进行HC2HPV-DNA检测,按检测结果分为HPV阴性组95名和阳性组57名,所有ASCUS妇女行阴道镜检查并宫颈活检和组织病理学检查,应用SPSS16.0软件进行数据统计分析。结果 152名ASCUS妇女中高危型HPV阳性57名,占36.8%;高危型HPV阳性组中宫颈活检病理阳性率63.2%,高危型HPV阴性组中宫颈活检病理阳性率3.2%,两组活检病理阳性率比较,差异有统计学意义(P<0.01);ASCUS妇女中宫颈活检病理宫颈上皮内瘤变(CIN)Ⅰ、CINⅡ阳性组44、13例,分别占77.2%、22.8%,阴性组95、0例,分别占100.0%、0,两组比较差异有统计学意义(P<0.05)。结论 HC2HPV-DNA检测是对宫颈细胞学ASCUS妇女最有效、简便、经济、无创的分流方法。
Objective To explore the value of detecting human papillomavirus (HPV) infection in shunt management of women with undifferentiated cervical atypical squamous cell carcinoma (ASCUS) to determine the appropriate shunt method. Methods The data of 5480 women who underwent cervical cytology (ICC) screening by TLCT from January 2009 to December 2012 were collected and 152 women with ASCUS diagnosed by TCT were enrolled in this study. HC2HPV According to the test results, the results were divided into HPV negative group of 95 and positive group of 57. All ASCUS women underwent colposcopy and cervical biopsy and histopathological examination. SPSS16.0 software was used for statistical analysis. Results Among 152 ASCUS women, 57 were high-risk HPVs, accounting for 36.8%. The positive rate of cervical biopsy in high-risk HPV positive group was 63.2%, and the positive rate of cervical biopsy in high-risk HPV negative group was 3.2% (P <0.01). Cervical biopsy specimens from ASCUS women with cervical intraepithelial neoplasia (CIN) Ⅰ and CINⅡpositive group (44,13 cases) were 77.2% and 22.8% respectively, with a negative rate of 95% 0 cases, respectively, 100.0%, 0, the difference between the two groups was statistically significant (P <0.05). Conclusion HC2HPV-DNA test is the most effective, simple, economical and noninvasive shunt method for cervical cytology ASCUS women.