论文部分内容阅读
目的:探讨肝动脉栓塞用多西他赛原位植烷三醇立方液晶的体内外药效。方法:利用MTT技术考察多西他赛原位植烷三醇立方液晶对肝癌细胞Hep G2的体外细胞毒性,建立兔VX2移植性肝癌模型评价其栓塞治疗肝癌的疗效。结果:体外结果表明,多西他赛原位植烷三醇立方液晶(IC50为12 nmol·L-1)比多西他赛溶液(IC50为1 200 nmol·L-1)对肝癌细胞Hep G2具有更强的诱导凋亡作用(P<0.05);体内结果显示,多西他赛原位植烷三醇立方液晶组的肿瘤生长速度与对照组相比明显受到抑制(P<0.05)。结论:多西他赛原位植烷三醇立方液晶在体内外对肝癌均有较强的疗效。
Objective: To investigate the in vivo and in vitro pharmacodynamics of docetaxel cisplatin in hepatic artery embolization in situ. Methods: MTT assay was used to investigate the in vitro cytotoxicity of docetaxel in situ on the hepatocellular carcinoma Hep G2 cells. The rabbit VX2 transplanted hepatocellular carcinoma model was established to evaluate the efficacy of embolization in the treatment of hepatocellular carcinoma. Results: In vitro results showed that docetaxel in situ phytantriol cubic liquid crystal (IC50 of 12 nmol·L-1) than docetaxel solution (IC50 of 1 200 nmol·L-1) on Hep G2 cells (P <0.05). The in vivo results showed that the tumor growth rate of docetaxel in situ cisplatin solution was significantly inhibited compared with the control group (P <0.05). Conclusion: Docetaxel in situ phytantriol cubic liquid crystal has a strong effect on liver cancer both in vitro and in vivo.