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本文调查了启东地区124例健康人外周血淋巴细胞微核率,结果表明:自发微核率为0.76±0.07‰,HBsAg 阳性率为23.40%;其中 HBsAg 阳性组微核率、微核人员出现率显著高于阴性组(P<0.05或<0.01)。提示 HBV 感染者体细胞染色体畸变、自发微核率明显上升,对人类遗传存在着致突变、致癌的潜在危险。
In this paper, we investigated the micronuclei frequency of peripheral blood lymphocytes in 124 healthy donors in Qidong. The results showed that the spontaneous micronucleus rate was 0.76 ± 0.07 ‰ and the positive rate of HBsAg was 23.40%. The incidences of micronuclei, micronuclei in HBsAg positive group Significantly higher than the negative group (P <0.05 or <0.01). It is suggested that the chromosomal aberrations of somatic cells in HBV infected individuals and the spontaneous micronucleus rate increase obviously, which may cause the potential risk of mutation and carcinogenesis to human heredity.