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目的：探讨急性脑梗死患者血浆内皮素（ＥＴ）的变化及其临床意义。方法：应用放射免疫分析法测定３７例急性脑梗死患者（观察组）和３４例健康人（对照组）的血浆ＥＴ含量。结果：脑梗死急性期患者血浆ＥＴ含量〔（６２．４９±５．７４）ｎｇ／Ｌ〕明显高于恢复期〔（５２．６８±５．２０）ｎｇ／Ｌ〕和对照组〔（５０．９４±６．０８）ｎｇ／Ｌ，Ｐ均＜０．００１〕；脑梗死中重度患者血浆ＥＴ含量〔（６４．１５±５．３６）ｎｇ／Ｌ〕明显高于轻度患者〔（５９．６９±５．３３）ｎｇ／Ｌ，Ｐ＜０．０５〕；急性期血浆ＥＴ水平与梗死灶体积的大小呈正相关（ｒ＝０．４５１９，Ｐ＜０．０１）。结论：ＥＴ参与了急性脑梗死的病理生理过程；监测脑梗死患者血浆ＥＴ水平可作为反映病情程度和评估预后的一项参考指标。
Objective: To investigate the changes of plasma endothelin (ET) in patients with acute cerebral infarction and its clinical significance. Methods: Plasma ET levels in 37 patients with acute cerebral infarction (observation group) and 34 healthy individuals (control group) were determined by radioimmunoassay. Results: The plasma ET level in patients with acute cerebral infarction 〔(62.49 ± 5.74) ng / L〕 〔was significantly higher than that in the recovery phase 〔(52.68 ± 5.20) ng / L〕 and the control group 〔(50. 94 ± 6.08) ng / L, P <0.001). The plasma ET level was significantly higher in moderate-severe cerebral infarction patients (64.15 ± 5.36 ng / L) than in mild patients 69 ± 5.33) ng / L, P <0.05]. There was a positive correlation between plasma ET level and infarct volume in acute phase (r = 0.4519, P <0.01). Conclusion: ET participates in the pathophysiological process of acute cerebral infarction. Monitoring plasma ET level in patients with cerebral infarction can be used as a reference index to reflect the severity of the disease and evaluate the prognosis.