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本文对原料及针、片剂型等用聚酰胺柱层析分离及紫外分光光度法测定黄芩甙给药后人体尿药含量。所得数据采用电子计算机非线性最小二乘法嵌合程序进行迭代处理得到药动学参数。从所得结果看:肌注与口服给药比较,前者吸收快(0.4小时即达尿药速度峰),生物利用度也较大(89.27％),而口服给药吸收缓慢(7～16小时才达高峰),生物利用度也低(22～36％)。黄芩甙肌注给药平均t(1/2)为0.62小时,在体内消除甚快。由此,临床上应用的每日一次肌注法欠合理。
In this paper, the raw materials and needles, tablets and other polyamide column chromatography and UV spectrophotometry Determination of human urine after baicalin drug levels. The data obtained using computer nonlinear least-squares chimeric procedures for iterative processing pharmacokinetic parameters. From the results obtained: intramuscular injection compared with oral administration, the former absorbed fast (0.4 hours reached the peak of urinary drug velocity), bioavailability is also greater (89.27%), and oral administration of slow absorption (7 to 16 hours before Reaching the peak), bioavailability is also low (22 ~ 36%). Baicalin intramuscular administration of the average t (1/2) was 0.62 hours, eliminate very quickly in the body. Thus, the clinical application of intramuscular once a day is not reasonable.