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目的对154对308例习惯性流产染色体核型进行分析。方法 2008-03-2012-03门诊就诊的154对习惯性流产夫妇308例,进行染色体核型和G带分析。结果 154对308例习惯性流产夫妇进行核型和G带分析分析,50例发现染色体核型异常,染色体核型异常发生率16.23%,其中男性发生染色体核型异常14例,女性发生染色体核型异常36例,男女比例1:2.57;6例臂间倒位占染色体核型异常12.00%,12例染色体变异占染色体核型异常24.00%,32例平衡易位占染色体核型异常64.00%。结论习惯性流产形成与夫妇双方染色体核型异常有着直接关系,在习惯性流产中进行染色体核型检查非常必要,可以对染色体核型异常携带者进行诊断,进行医学遗传学理论指导。
Objective To analyze the chromosomal karyotypes of 154 pairs of 308 cases of habitual abortion. Methods From March 2008 to March 2008, 308 outpatients, including 308 habitual abortion couples, were analyzed for karyotype and G band. Results A total of 154 cases of 308 cases of habitual abortion were analyzed by karyotype and G band. In 50 cases, chromosomal karyotype was abnormal, the incidence of chromosomal abnormalities was 16.23%, of which 14 cases were found abnormal in males and 14 cases were found in females Abnormalities in 36 cases, male to female ratio of 1: 2.57; 6 cases of arm inverted chromosome abnormalities accounted for 12.00%, 12 cases of chromosomal abnormalities accounted for 24.00% of chromosomal abnormalities, 32 cases of balanced translocations accounted for chromosomal abnormalities 64.00%. Conclusion The formation of habitual abortion is directly related to the chromosomal abnormalities in both couples. Chromosomal karyotyping is very necessary in habitual abortion. It can diagnose chromosomal aberrations and guide medical genetics.