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目的:研究即分化抑制因子-1(Id1)在腺样囊性癌的表达及其与腺样囊性癌临床病理特征、肿瘤血管生成的关系。方法:免疫组化EnvisionTM法检测46例腺样囊性癌组织和10例正常唾液腺组织Id1的表达,检测CD34的表达,对肿瘤组织微血管密度进行计数。应用SPSS16.0软件对实验数据进行统计学分析。结果:Id1在腺样囊性癌中表达阳性率为65.2%,显著高于正常唾液腺组(P<0.01)。Id1表达与腺样囊性癌病理分型、临床分期、及肿瘤转移显著相关(P<0.05),与患者的性别和年龄无显著性相关(P>0.05)。Id1在腺样囊性癌中的表达与CD34标记的肿瘤微血管密度密切相关。结论:Id1的表达与腺样囊性癌临床病理特征密切相关,Id1可能通过促进腺样囊性癌的血管生成而与肿瘤的发展和转移密切相关。
Objective: To investigate the expression of Id-1 in adenoid cystic carcinoma and its relationship with the clinicopathological features and tumor angiogenesis in adenoid cystic carcinoma. Methods: Immunohistochemical EnvisionTM method was used to detect the expression of Id1 in 46 adenoid cystic carcinoma and 10 normal salivary gland tissues. The expression of CD34 was detected and the microvessel density of the tumor tissue was counted. The experimental data were analyzed by SPSS16.0 software. Results: The positive rate of Id1 in adenoid cystic carcinoma was 65.2%, which was significantly higher than that in normal salivary gland (P <0.01). The expression of Id1 was significantly associated with pathological type, clinical stage and metastasis of adenoid cystic carcinoma (P <0.05), but not with gender and age (P> 0.05). The expression of Id1 in adenoid cystic carcinoma is closely related to the CD34-labeled tumor microvessel density. Conclusions: The expression of Id1 is closely related to the clinicopathological features of adenoid cystic carcinoma. Id1 may be closely related to tumor development and metastasis by promoting angiogenesis of adenoid cystic carcinoma.