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目的:观察腰椎“椎骨错缝”大鼠模型造模节段生物力学及坐骨神经传导速度的变化。方法:将160只350~450 g雄性SD大鼠随机分为实验组、对照组、假手术组及空白对照组。再将各组按固定时间分为1、2、4、8和12周5个亚组。实验组和对照组通过外科手术方法在其L4、L5和L6棘突上均植入外固定连接装置的棘突附着部件,实验组在此基础上再植入外部连接部件,假手术组仅行手术干预,空白对照组不行任何干预。在各连接期结束时,脊柱刚度测试系统检测实验组和对照组固定节段刚度;肌电诱发电位仪检测各组坐骨神经传导速度。结果:刚度检测结果显示实验组大鼠脊柱造模节段刚度随连接时间的延长而增加,其中从8周开始实验组刚度出现明显变化。神经电生理示造模节段相应脊神经传导速度逐渐减慢。结论:椎骨错缝大鼠模型可引起相应造模节段脊椎生物力学特性的变化及神经电生理的改变,且此种变化与时间相关。
OBJECTIVE: To observe the changes of biomechanics and sciatic nerve conduction velocity in the model segment of lumbar spondylolisthesis. Methods: 160 male SD rats weighing 350-450 g were randomly divided into experimental group, control group, sham operation group and blank control group. The groups were divided into five subgroups of 1, 2, 4, 8 and 12 weeks according to a fixed time. The experimental group and the control group received surgical attachment of the spinous process on the L4, L5 and L6 spinous processes, respectively. The experimental group was then implanted with external connection components. The sham operation group Surgical intervention, blank control group without any intervention. At the end of each connection period, the spinal stiffness test system was used to measure the stiffness of the fixed segments in the experimental and control groups. The sciatic nerve conduction velocity was measured by electromyography. Results: The results of stiffness test showed that the rigidity of the spinal model segment in the experimental group increased with the prolongation of the connection time, and the stiffness of the experimental group changed significantly from the 8th week. Neural electrophysiological modeling section of the corresponding spinal nerve conduction velocity gradually slowed down. Conclusion: The rat model of vertebral fracture can cause changes of biomechanical properties and electrophysiological changes of vertebra in the corresponding model segment, and this change is correlated with time.