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目的观察门冬氨酸-鸟氨酸联合乳果糖治疗肝性脑病临床疗效。方法肝性脑病60例。随机分为两组。治疗组和对照组各30例。治疗组给予门冬氨酸-鸟氨酸静脉点滴注及乳果糖灌肠治疗。对照组给予谷氨酸钠或谷氨酸钾静滴。食醋灌肠。两组疗程10d。观察患者治疗前后的临床表现(症状和体征的变化)并检测血氨及肝肾功能判断临床疗效。结果 10d后治疗组血氨水平下降,肝肾功能指标恢复以及临床表现均优于对照组。结论门冬氨酸-鸟氨酸联合乳果糖能有效改善肝功能、降低血氨,显著提高肝性脑病的治愈率。值得临床推广使用。
Objective To observe the clinical efficacy of aspartate-ornithine combined with lactulose in the treatment of hepatic encephalopathy. Methods Hepatic encephalopathy in 60 cases. Randomly divided into two groups. The treatment group and the control group of 30 cases. The treatment group was given aspartate-ornithine intravenous infusion and lactulose enema treatment. The control group was given sodium glutamate or potassium glutamate intravenous infusion. Vinegar enema. Two groups of treatment 10d. Before and after treatment of patients with clinical manifestations (symptoms and signs of change) and detection of serum ammonia and liver and kidney function to determine the clinical efficacy. Results After 10 days, the level of serum ammonia decreased, the indexes of liver and kidney function recovered and the clinical manifestations were better than the control group. Conclusion Aspartate-Ornithine combined with lactulose can effectively improve liver function, lower blood ammonia, significantly improve the cure rate of hepatic encephalopathy. It is worth to promote clinical use.