采用胰岛素敏感性指数检测妊娠期糖尿病的一项初步研究

• 作 者: Kauffman R.P. Castracane V.D. Peghee D. 朱磊
• 机 构: Department of Obstetrics and Gynecology Texas Tech University Health Sciences Center School of Medi
• 出 处: 世界核心医学期刊文摘(妇产科学分册)
• 发表日期: 2006年11期
• 关键词: 妊娠期糖尿病 空腹胰岛素 胰岛素 口服葡萄糖 糖筛查 空腹血糖 检测 内环境稳定 筛查手段 水平测试

Objective: We investigated whether homeostatic indices of insulin sensitivity might suitably screen for gestational diabetes mellitus. Study design: One hundred twenty-three pregnant women who were between 24 and 28 weeks of gestation completed a 3- hour 100 g oral glucose challenge test and fasting insulin level in a nested case-control study design. Insulin sensitivity indices were calculated and tested for their ability to detect gestational diabetes mellitus. Results: Fasting glucose demonstrated the best overall accuracy, but the homeostasis model assessment and quick insulin sensitivity check index were also sensitive screening techniques for gestational diabetes mellitus when either the National Diabetes Data Group or Carpenter-Coustan criteria were used. Conclusion: Homeostasis model assessment, quick insulin sensitivity check index, and fasting glucose are sensitive screening tests for gestational diabetes mellitus and can avoid oral administration of glucose-containing solutions.

Objective: We asked whether homeostatic indices of insulin sensitivity might adequate screen for gestational diabetes mellitus. Study design: One hundred twenty-three pregnant women who were between 24 and 28 weeks of gestation completed a 3- hour 100 g oral glucose challenge test and fasting Insulin sensitivity in were tested and their fitness to detect gestational diabetes mellitus. Results: Fasting glucose demonstrated the best overall accuracy, but the homeostasis model assessment and quick insulin sensitivity check index also also sensitive screening techniques for gestational diabetes mellitus when either the National Diabetes Data Group or Carpenter-Coustan criteria were used. Conclusion: Homeostasis model assessment, quick insulin sensitivity check index, and fasting glucose are sensitive screening tests for gestational diabetes mellitus and can avoid oral administration of glucose-containing soluti ons.