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目的:探讨更年期功能失调性子宫出血采用米非司酮治疗的临床效果。方法:选取2014.7~2016.2期间我院收治的40例更年期功能失调性子宫出血患者,采用双盲法随机将患者分为常规组(丙酸睾丸酮联合甲基睾丸素用药)、治疗组(用药米非司酮),每组人数均为20例,评估疾病治疗效果,观察两组治疗后各激素指标水平变化及不良反应情况。结果:常规组治疗期间,14例患者闭经,随访中6例患者复发,治疗有效率70.0%;治疗组治疗期间,20例患者均闭经,随访中1例月经恢复正常,19例绝经,治疗有效率100%。两组相比较,差异具有统计学意义(P<0.05)。用药前两组患者各激素水平无统计学差异,(P>0.05);用药后治疗组FSH、LH、E_2、P水平均明显低于常规组,其下降幅度明显优于常规组,差异具有统计学意义(P<0.05)。结论:临床更年期功能失调性子宫出血患者,使用米非司酮治疗,能有效改善病症、促进子宫功能恢复,安全有效,不良反应少,值得临床推广。
Objective: To investigate the clinical effect of mifepristone treatment for menopausal dysfunctional uterine bleeding. Methods: Forty patients with menopausal dysfunctional uterine bleeding who were treated in our hospital from July 2014 to 2016.2 were enrolled. Patients were randomly divided into routine group (testosterone propionate plus methyltestosterone) by double-blind method, treatment group Division ketones), each of the number of patients were 20 cases, evaluate the effect of disease treatment, observation of the two groups of hormone levels after treatment and adverse reactions. Results: In the control group, 14 patients recovered from amenorrhea and follow-up, the response rate was 70.0%. During the treatment group, all the 20 patients were amenorrhea. One patient had normal menstruation and 19 menopause. Efficiency 100%. The difference between the two groups was statistically significant (P <0.05). The levels of FSH, LH, E_2, P in the two groups before treatment were significantly lower than those in the control group (P> 0.05), and their decreasing rates were significantly better than those in the conventional group Significance (P <0.05). Conclusion: Clinical climacteric dysfunctional uterine bleeding patients, the use of mifepristone treatment, can effectively improve the symptoms and promote uterine function recovery, safe and effective, less adverse reactions, is worth clinical promotion.