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目的探讨脑白质疏松症(LA)患者认知功能、血浆同型半胱氨酸(Hcy)水平与颈动脉血流动力学指标的关系。方法测试LA患者认知损害水平,根据结果分为三组,分别为痴呆组、轻度认知功能障碍组和无认知功能障碍组。根据三组患者的血浆Hcy水平及颈部血管超声血流动力学指标进行相关性分析。结果痴呆组患者的血浆Hcy水平较轻度认知功能障碍组与无认知功能障碍组增高(P<0.05),双侧颈内动脉阻力指数(RI)、搏动指数(PI)亦较轻度认知功能障碍组与无认知功能障碍组增高(P<0.05)。结论 LA患者不同水平认知功能与血浆Hcy水平和颈部血管超声变化存在相关性,血浆Hcy水平越高,RI和PI越高,则认知损害越重。
Objective To investigate the relationship between cognitive function, plasma homocysteine (Hcy) and carotid hemodynamics in patients with leukoaraiosis (LA). Methods The levels of cognitive impairment in LA patients were divided into three groups according to the results: dementia group, mild cognitive impairment group and no cognitive impairment group. According to the three groups of patients with plasma Hcy levels and cervical vascular ultrasound hemodynamics correlation analysis. Results The level of Hcy in patients with dementia was higher than that in patients with mild cognitive impairment and no cognitive impairment (P <0.05), and RI and PI of bilateral carotid arteries were also mild Cognitive impairment group and no cognitive impairment group increased (P <0.05). Conclusion Cognitive function at different levels in patients with LA has correlation with plasma Hcy level and ultrasonic changes of cervical vessels. The higher plasma Hcy level and the higher RI and PI, the more severe cognitive impairment.