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目的：用双盲对照法比较普萘洛尔与维拉帕米治疗抗精神病药所致窦性心动过速（简称窦速）的疗效。方法：因服抗精神病药物后引起窦速１００例，分为甲、乙２组。甲组５０例（男性３１例，女性１９例；年龄３２±ｓ１３ａ）采用普萘洛尔１０ｍｇ，ｐｏ，ｔｉｄ×２ｗｋ．乙组５０例（男性３１例，女性１９例；年龄３３±１２ａ）采用维拉帕米２０ｍｇ，ｐｏ，ｔｉｄ×２ｗｋ。结果：甲组痊愈４３例，有效７例；乙组痊愈１９例，有效２１例，无效１０例，经Ｒｉｄｉｔ分析法统计，Ｐ＜０．Ｏ５；２组均无明显不良反应。结论：治疗抗精神病药物性引起的窦速普萘洛尔优于维拉帕米。
Objective: To compare the efficacy of propranolol and verapamil in the treatment of sinus tachycardia (referred to as sinus speed) caused by antipsychotics by double-blind control. Methods: Due to taking antipsychotics cause sinus speed 100 cases, divided into A, B group. A group of 50 patients (31 males and 19 females; age 32 ± s13a) with propranolol 10mg, po, tid × 2wk. Group B 50 cases (31 males, 19 females; age 33 ± 12a) with verapamil 20mg, po, tid × 2wk. Results: A group of 43 cases were cured, effective in 7 cases; B group cured 19 cases, 21 cases effective, ineffective in 10 cases, Ridit analysis statistics, P <0. O5; 2 groups had no obvious adverse reactions. CONCLUSIONS: Propranolol, a sinusoidal effect caused by antipsychotic medication, is superior to verapamil.