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阿司匹林抵抗是指患者规律服用常规剂量的阿司匹林仍不能减少临床动脉血栓栓塞性缺血事件的发生。目前,用于检测阿司匹林抵抗的实验室方法主要包括检测血栓素A2的生成和依赖于血栓素的血小板功能,且研究表明,阿司匹林抵抗的实验室检测结果与心血管事件的危险性增高呈独立相关。然而,目前实验室诊断阿司匹林抵抗尚无统一的标准。现就近年来有关阿司匹林抵抗的实验室检测研究进展作一综述。
Aspirin resistance refers to patients regularly taking regular doses of aspirin still can not reduce the incidence of clinical arterial thromboembolic ischemic events. At present, the laboratory methods used to detect aspirin resistance mainly include the detection of thromboxane A2 production and thromboxane-dependent platelet function, and studies have shown that the aspirin resistance laboratory test results are independently associated with the increased risk of cardiovascular events . However, there is no uniform standard for laboratory diagnosis of aspirin resistance. In recent years, the progress of laboratory testing on aspirin resistance is reviewed.