Prioritization of orphan disease-causing genes using topological feature and GO similarity between

• 作 者: LI Min LI Qi GANEGODA Gamage U
• 机 构: SchooloflnformationScienceandEngineering,CollegeofEngineering,DepartmentofComputerScience
• 出 处: 中国科学：生命科学英文版
• 发表日期: 2014年11期
• 关键词: 蛋白质相互作用网络 语义相似度 致病基因 拓扑 蛋白相互作用 人类疾病 生物实验 基因本体论 disease-causing genes prioritiza
• 基金项目: supported in part by the National Natural Science Foundation of China(61370024,61428209,61232001),Program for New Century Excellent Talents in University(NCET-12-0547)

Identification of disease-causing genes among a large number of candidates is a fundamental challenge in human disease studies.However,it is still time-consuming and laborious to determine the real disease-causing genes by biological experiments.With the