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目的 :探讨Hp与胃腺癌的相关性 ,特别是cagA因子与胃腺癌的相关性。 方法 :利用血抗Hp IgG、RUT、PCR Hp DNA 3种方法检测 2 70例病人耳垂血或胃粘膜活检组织中的Hp及其cagA基因。 结果 :Hp感染率为 6 8 5 2 % (无性别差异 ) ,cagA+ Hp感染率为 5 4 73% (男性 6 4 0 0 % >女性 41 94% ,P <0 0 5 )。cagA+ Hp致胃炎程度及活动性均较cagA-Hp及Hp 者高 (P <0 0 5 ) ;男性感染cagA+ Hp更易发展为CAG、IM (P <0 0 5 ) ;感染Hp者胃腺癌的分化程度低 ,且向周围浸润及淋巴结转移的能力强 (P <0 0 5 ) ,但与cagA因子无关 (P >0 0 5 ) ;非贲门腺癌患者血抗Hp IgG抗体阳性率为 76 32 % ,大于贲门癌 (5 2 90 % ) (P <0 0 5 )。 结论 :Hp感染与胃腺癌发生、发展相关 ;cagA因子可能为胃腺癌 ,特别是男性胃腺癌的致癌因子之一 ,主要作用于胃腺癌发生的早期阶段
Objective: To investigate the correlation between Hp and gastric adenocarcinoma, especially the correlation between cagA factor and gastric adenocarcinoma. METHODS: Hp and cagA genes were detected in blood biopsy tissues of 270 patients with ear lobe or gastric mucosa using 3 methods: anti-Hp IgG, RUT and PCR Hp DNA. RESULTS: The Hp infection rate was 68.52% (without gender difference), and the cagA+ Hp infection rate was 5 4 73% (male 640%> female 41 94%, P <0 05). CagA+Hp induced gastritis and the activity was higher than that of cagA-Hp and Hp (P<0.05). Male infection with cagA+Hp was more likely to develop into CAG and IM (P<0.05). The differentiation of gastric adenocarcinoma in patients with Hp infection Low degree, strong ability to infiltrate into the surrounding and lymph node metastasis (P <0 05), but not cagA factor (P> 0 05); non-cardiac adenocarcinoma patients anti-Hp IgG antibody positive rate was 76 32% , More than cardiac cancer (5 2 90%) (P <0 0 5). Conclusion : Hp infection is related to the occurrence and development of gastric adenocarcinoma; cagA factor may be one of the carcinogenesis factors of gastric adenocarcinoma, especially male gastric adenocarcinoma, and it is mainly responsible for the early stage of gastric adenocarcinogenesis.