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近年来发现用杂交法测定人体淋巴细胞的单克隆抗体(OKT 以及Leu 系列)能识别淋巴细胞的功能和分化,可用于诊断神经系免疫性疾病,如多发性硬化症(MS)、重症肌无力(MG)、Guillain-Barre 氏症群(GBS)、多发生肌炎(PM)等,并用免疫法有助于阐明病因,诊断疾病和予测病程。Ⅰ.多发性硬化症作为脱髓性代表性疾病,一般认为与某种病毒感染或免疫异常有关。Reinherz等报告MS 活动期OKT_6阳性细胞减少,提示MS 发病
In recent years, it has been found that monoclonal antibodies (OKT and Leu series) for measuring human lymphocytes by hybridization can recognize the function and differentiation of lymphocytes and can be used for diagnosis of neurological immune diseases such as multiple sclerosis (MS), myasthenia gravis (MG), Guillain-Barre’s syndrome (GBS), polymyositis (PM), and so on. Immunoassay can help elucidate the etiology, diagnose the disease and predict the course of the disease. Ⅰ. Multiple sclerosis, as a typical demyelinating disease, is generally considered to be associated with a viral infection or an immune disorder. Reinherz and other reports of MS activity of OKT_6-positive cells decreased, suggesting that the incidence of MS